The first big screen appearance for Malcolm McDowell was in Poor Cow (1967), although his two-minute scene was ultimately cut from the completed film. Soon after, he caught the attention of director Lindsay Anderson who cast him in the role of a rebellious student in his film If.... (1968). The film catapulted Malcolm to stardom in Britain but failed everywhere else. He was so enthusiastic about the film's success that he wanted to do another right away. He began writing what would become the semi-autobiographical O Lucky Man! (1973).

Then he starred as Alex DeLarge in Stanley Kubrick's controversial A Clockwork Orange (1971), a role that gave him world fame, and legendary status (although typecasting him as a in villainous roles). In early 1976, he spent nearly a year working on what would later be one of the most infamous films of all time, the semi-pornographic Caligula (1979), financed by Penthouse magazine founder Bob Guccione. Around that time, the British film industry collapsed, forcing him to flee to America to continue working. His first American film was Time After Time (1979). He then did Britannia Hospital (1982), the last part of Lindsay Anderson's working-class trilogy that started with If.... (1968).

In 1994, he was cast as Dr. Tolian Soran, the man who killed Captain James T. Kirk in Star Trek: Generations (1994). He was back on the track, playing villains again. He played another in the classic BBC miniseries Our Friends in the North (1996). Today, with more than 100 films under his belt, he is one of the greatest actors in America. In 2021 McDowell got his American citizenship. Prior to getting his citizenship, McDowell has stated that he likes the no-nonsense American ways. He resides in the northern suburbs of Los Angeles, California.